Cannabidiol (CBD) goods are not only some of the hottest cannabis products on the market, but they are also taking the nutritional supplement world by storm. But, is the compound actually safe? Does CBD have side effects? To answer some serious questions about the popular compound, here’s what research has to say about the potential side effects of CBD.
Does CBD have side effects?
Just like any other supplement or substance, CBD can come with some side effects. Generally speaking, the cannabis compound is considered non-toxic and is well-tolerated in most early clinical trials.
However, high doses of the molecule may have some undesirable side effects for some people.
CBD is being explored as a safer and potentially more effective alternative to some pharmaceutical medications. These include drugs given to epileptic children as well as adults with schizophrenia, and neurological disorders.
Much of the research thus far suggests that CBD is generally safe offers improvements in quality of life for a wide variety of medical conditions. A 2011 study published in Current Drug Safety found that doses up to 1,500 milligrams of CBD were well tolerated.
Another small study published in 1986 found that doses between 100 and 600 milligrams of CBD were associated with mild side effects like dry mouth, sleepiness, lowered blood pressure, and dizziness.
Some side effects in high doses
However, a human clinical trial examining the effects of high-dose CBD have found that the cannabinoid (cannabis compound) have reported some negative side effects, including:
- Drowsiness and sleep
- Nausea or vomiting
- Lack of appetite
- Raised body temperature
These side effects were found in epilepsy patients who received an isolated dose of CBD in the form of the pharmaceutical drug Epidiolex.
The dosage given was 20 milligrams per kilogram of body weight per day. This is an extremely high dose. At this rate, a person weighing 158 pounds (72 kilos) would be taking roughly 1440 milligrams of CBD.
83 percent of the 120 participants in the above study reported that side effects were mild to moderate.
When to be cautious with CBD
Most consumers taking CBD supplements or vaporizing high-CBD flowers or concentrates do not consume anywhere near the amount of CBD used in the study mentioned above.
It’s possible that many of the side effects mentioned above are not present in low or average doses.
However, there are a few moments when you may want to be cautious with CBD. It is important to be mindful of possible side effects when taking very high doses of the cannabis compound.
Those taking pharmaceutical medications may also want to closely monitor side effects and work with a medical professional when adding CBD to their treatment plan.
Preliminary research suggests that CBD may block detoxifying enzymes in the liver. Blocking these enzymes might mean that the liver cannot properly cleanse the body of excess pharmaceutical drugs.
Worst case scenario, this potentially causes an unsafe buildup of pharmaceuticals in the bloodstream and doses of either the CBD or the drugs in question need to be lowered. Interestingly, compounds in grapefruit have similar properties.
When starting with CBD, it’s important to talk with a doctor if you are taking pharmaceutical medications. Otherwise, keeping doses low is recommended unless you’re working with a medical professional.